PZFlex Ultrasound Catheter for Microbubble Based drug delive

Abstract— An intravascular ultrasound (IVUS) catheter was
designed to guide and locally deliver microbubbles carrying
therapeutic agents. Optimal insonation parameters were
determined by modeling microbubble translational
displacements using the coupled 1D Rayleigh-Plesset and Dragdisplacement
equations. A transducer assembly was designed
based on the results of microbubble simulations and a Finite
Element Analysis (FEA) Model. The transducer components
were fabricated then assembled into a 1.4 mm (OD) catheter
tube. Hydrophone tests were performed to measure
transducer output and the resulting output was compared to
the FEA model.